Profil Senyawa Daun Kelor (Moringa Oleifera) Dari Gc-Ms Sebagai Kandidat Ergogenik Antifatigue

Aditya Candra, Tahara Dilla Santi, Maidayani Maidayani, Syarifah Nora Andriaty, Mardiati Mardiati, Said Aandy Saida, Ika Waraztuty, Farid Bastian

Abstract


Fatigue is a body condition that is not optimal due to lack of energy due to excessive and continuous physical activity. This research aims to determine the compounds contained in Moringa oleifera leaves which function as antifatigue. Testing The content of compounds that act as antifatigue was obtained through the GC-MS test. The GC-MS test results obtained 10 metabolite compounds from Moringa oleifera leaves which act as antifatigue, namely neophytadiene; hexadecanoic acid, ethyl ester; phytol; 9,12,15- octadecatrienoic acid, ethyl ester; octadecanoic acid, ethyl ester; linolenic acid; methyl 8,11,14-heptadecatrienoate; squalene; gamma-tocopherol; vitamin E. This research proves that the compounds contained in Moringa oleifera leaves have an antifatigue effect.


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Adebayo, I. A., Arsad, H., & Samian, M. R. (2018). Total Phenolics, Total Flavonids, Antioxidant Capacities, and Volatile Compounds Gas Chromatography-Mass Spectrometry Profiling of Moringa oleifera Ripe Seed Polar fractions (pp. 191–194). pp. 191–194. https://doi.org/doi: 10.4103/pm.pm_212_17

Ardila, S., Wahab, A., Candra.A. (2023). Antibacterial Effectiveness Test Of Kersen Leaves (Muntingia Calabural L) On Escherichia Coli. Medalion Journal: Medical Research, Nursing, Health And Midwife Participation.pp 100-105

Azad, S. Bin, Ansari, P., Azam, S., Hossain, S. M., Shahid, M. I. Bin, Hasan, M., & Hannan, J. M. A. (2017). Anti-hyperglycaemic activity of Moringa oleifera is partly mediated by carbohydrase inhibition and glucose-fibre binding. Bioscience Reports, 37(3), 1–11. https://doi.org/10.1042/BSR20170059

Candra, A., Santi TD. (2017). Efektivitas ekstrak daun pepaya (Carica papaya L) sebagai antiinflamasi. Jurnal Aceh Medika.pp 63-66

Candra,A., Rusip, G, Machrina, Y. (2016). Pengaruh Latihan Aerobik Terhadap Asam Laktat Dan Skala Borg Atlet Sepakbola. Pp 7-13

Candra, Aditya; Yudha Fahrimal, Yusni, Azwar, Santi, Tahara Dilla. (2023). Soil Chemistry, Phytochemistry, And Gc-Ms Profiles Of Moringa Leaves (Moringa oleifera) As An Antifatigue Candidate From Geothermal, Coastal, And Urban Areas In Aceh Besar District And Banda Aceh Municipality, Indonesia. Rasayan J. Chem, 16(3), 1333-1341. http://doi.org/10.31788/RJC.2023.1638128

Egan, B., & Zierath, J. R. (2013). Exercise metabolism and the molecular regulation of skeletal muscle adaptation. Cell Metabolism, 17(2), 162–184. https://doi.org/10.1016/j.cmet.2012.12.012

Ekong, M. B., Ekpo, M. M., Akpanyung, E. O., & Nwaokonko, D. U. (2017). Neuroprotective effect of Moringa oleifera leaf extract on aluminium-induced temporal cortical degeneration. Metabolic Brain Disease, 32(5), 1437–1447. https://doi.org/10.1007/s11011-017-0011-7

El-Khadragy, M. et al. (2018) ‘Clinical efficacy associated with enhanced antioxidant enzyme activities of silver nanoparticles biosynthesized using moringa oleifera leaf extract, against cutaneous leishmaniasis in a murine model of leishmania major’, International Journal of Environmental Research and Public Health. doi: 10.3390/ijerph15051037.

Gupta, R., Mathur, M., Bajaj, V. K., Katariya, P., Yadav, S., Kamal, R., & Gupta, R. S. (2012). Evaluation of antidiabetic and antioxidant activity of Moringa oleifera in experimental diabetes. Journal of Diabetes, 4(2), 164–171. https://doi.org/10.1111/j.1753-0407.2011.00173.x

Guyton, A. C., & Hall, J. E. (2006). Textbook of Medical Physiology, Eleventh Edition. Philadelphia: Elsevier Inc.

Hoffman, N. J., Parker, B. L., Chaudhuri, R., Fisher-Wellman, H., K. K., Humphrey, M. S. J., James, and D. E. (2015). Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates (pp. 922–935). pp. 922–935. https://doi.org/http://dx.doi.org/10.1016/j.cmet.2015.09.001

Laila, S., Candra, A (2022). Hubungan faktor risiko hiperlipidemia dan merokok terhadap penyakit jantung koroner di rumah sakit meuraxa. Jurnal Kandidat Riset dan Inovasi Pendidikan. Pp 74-81

Laursen, PB. 2005. Models to Explain Fatigue during Prolonged Endurance Cycling. Sports Med 2005; vol 35 (10): pp 865-898.

Leone, A. et al. (2018) ‘Effect of moringa oleifera leaf powder on postprandial blood glucose response: In vivo study on saharawi people living in refugee camps’, Nutrients, 10(10), pp. 1–14. doi: 10.3390/nu10101494.

M. Valko, D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur, J. Telser. (2007). Free radicals and antioxidants in normal physiological functions and human disease. The International Journal of Biochemistry & Cell Biology, 39, pp. 44-84

N.A. Shevchuk (2007). Possible use of repeated cold stress for reducing fatigue in chronic fatigue syndrome: a hypothesis. Behavioral and Brain Functions, 3, pp. 55-80

Nwidu, L., Elmorsy, E., Aprioku, J., Siminialayi, I., & Carter, W. (2018). In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts of Moringa oleifera Plants from Rivers State, Niger Delta, Nigeria. Medicines, 5(3), 71. https://doi.org/10.3390/medicines5030071

P. Pacher, J.S. Beckman, L. Liaudet. (2007). Nitric oxide and peroxynitrite in health and disease. Physiological Reviews, 87, pp. 315-424

Paikra, B. K., Dhongade, H. K. J., & Gidwani, B. (2017). Phytochemistry and pharmacology of Moringa oleifera Lam. Journal of Pharmacopuncture, 20(3), 194–200. https://doi.org/10.3831/KPI.2017.20.022

Paula, P. C., Sousa, D. O. B., Oliveira, J. T. A., Carvalho, A. F. U., Alves, B. G. T., Pereira, M. L., … Bulet, P. (2017). A protein isolate from Moringa oleifera leaves has hypoglycemic and antioxidant effects in alloxan-induced diabetic Mice. Molecules, 22(2). https://doi.org/10.3390/molecules22020271

Perez-Morala, N., Sahaa, S., Philoa, M., Harta, D. J., Winterbonea, M. S., Hollandsa, W. J., Curtisc, P. J. (2018). Comparative bio-accessibility, bioavailability and bioequivalence of quercetin, apigenin, glucoraphanin and carotenoids from freeze-dried vegetables incorporated into a baked snack versus minimally processed vegetables: Evidence from in vitro models and a (pp. 410–419). pp. 410–419. Norwich, UK: Journal of Functional Foods.

Sadek, K. M., Abouzed, T. K., Abouelkhair, R., & Nasr, S. (2017). The chemo-prophylactic efficacy of an ethanol Moringa oleifera leaf extract against hepatocellular carcinoma in rats (pp. 1458–1466). pp. 1458–1466. https://doi.org/DOI: 10.1080/13880209.2017.1306713

Santi. TD. (2019). Effect of Moderate Physical Activity to Muscle Fatigue on Untrained People. IOP Conference Series: Materials Science and Engineering, 506(1). https://doi.org/10.1088/1757-899X/506/1/012028

Santi, TD. (2015). Uji Toksisitas Akut dan Efek Antiinflamasi Ekstrak Metanol dan Ekstrak n-Heksana Daun Pepaya (Carica papaya L). Pharmaceutical Sciences and Research, 2(2), 101–114. https://doi.org/10.7454/psr.v2i2.3341

Sosa-Gutiérrez, J. A., Valdéz-Solana, M. A., Forbes-Hernández, T. Y., Avitia-Domínguez, C. I., Garcia-Vargas, G. G., Salas-Pacheco, J., Sierra-Campos, E. (2018). Effects of Moringa oleifera Leaves Extract on High Glucose-Induced Metabolic Changes in HepG2 Cells (pp. 1–19). pp. 1–19. Mexico: MDPI.

T.L. Clanton. (2007). Hypoxia-induced reactive oxygen species formation in skeletal muscle.

Journal of Applied Physiology, 102, pp. 2379-2388

Valdez-Solana, M. A. et al. (2015) ‘Nutritional content and elemental and phytochemical analyses of moringa oleifera grown in Mexico’, Journal of Chemistry, 2015. https://doi.org/10.1155/2015/860381

Zeng, B., Sun, J. J., Chen, T., Sun, B. L., He, Q., Chen, X. Y., … Xi, Q. Y. (2016). Effects of Moringa oleifera silage on milk yield, nutrient digestibility and serum biochemical indexes of lactating dairy cows. https://doi.org/DOI: 10.1111/jpn.12660


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