Detection MicroRNAs as potential biomarkers non invasive and targeted therapy for several cancer

Y. Bintoro, A Surono, Sofia M Haryana

Abstract


MicroRNAs (MiRNAs) is small molecule non coding RNAs that consist of 18-25 nucleotide. It is important to control gene expression by affected post transcriptional and translational repression of mRNA. This RNA molecule may as oncogene miRNA (OncomiR) or tumor supresor gene (TSmiR). Lowest or enhanced of miRNA associated to increase development cancer cell, cardiovascular disease, metabolisme disease and immune disorders. The
advantages of miRNA is about their stability in cell, body fluid that always stable under harsh condition as high temperature, different pH values, repeated freeze-thaw cycles and longtime storage. They are present not only in blood but also in formaline-fixed and paraffin embedded years before.The detection of miRNA in blood plasma and serum has potential for earlier cancer diagnostic and prognostic and response to therapy. In this review, providing researchers to increase understanding a glance of miRNA, biogenesis and their function.Better understanding may help to find spesifict biomarker for diagnosis and prognosis also to predict cancer targeted therapy.


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