PERBANDINGAN EFEKTIFITAS KLINIS TOPIKAL NIACINAMIDE 4% DAN TOPIKAL CLINDAMYCIN PADA ACNE VULGARIS RINGAN-SEDANG

Abstrak

Abstract: Niacinamide or nicotinamide is a potential anti-inflammatory for various skin diseases. Inflammatoryreduction acts as the main mechanism of niacinamide in the treatment of acne vulgaris. In a recent study it wasstated that the use of niacinamide is well tolerated by the skin, even able to produce beneficial effects such as canreduce sebum production. Topical Niacinamide produces a good anti-inflammatory effect and does not triggerbacterial resistance. This study aims to compare the clinical effectiveness of 4% topical niacinamide andclindamycin 1% topical in mild-moderate acne vulgaris at the Abulyatama University Medical School in BandaAceh. others were conducted on April 27 to June 8, 2018. The respondents were 7 respondents who were obtained ina double-blind randomized control trial design. The results of the study generally show that there is no significantdifference between acne vulgaris and clindamycin 1%. Where it is found that the T-Test test value is 1.025 <2.5706,there is no significant difference between acne vulgaris and niacinamide 1%, which found that the T test value -Test2,390 <2,5706. Based on the results above, it was found that in the use of topical drugs there will be differencesincluding depending on drug match and type of face so that it can affect the treatment process.